Buffalo 21 - New England 17 (NE -10)
Tennessee 10 - Pittsburgh 2 (Pittsburgh -6)
Oakland 17 - Indianapolis 14 (Indianapolis -11)
These are the three largest spreads in the early games, and you can see what is transpiring. Now by games end all three favorites may cover (highly doubtful IMO), but you get my point here.
Crazy shit can happen in the NFL, or any sport.
Its a long season, there will be many great opportunities to unload throughout the year - week #1 NFL is not ideal time to so.
Caution Is KEY!!